Course Videos
In what specific surgical procedures — from orthopedics to colorectal surgery — is IV acetaminophen indicated as a core agent in the context of multimodal management and ERAS? And what are the indications for this agent?
What is the exact dosing schedule you recommend and use for acetaminophen? Why do you feel that IV acetaminophen is preferable to the oral formulation and what is the effect of IV opioids on absorption and blood levels or oral acetaminophen? ...
From a practical perspective, what is the optimal dosing strategy for deploying IV acetaminophen and how should it be combined with IV or opioid therapy? What is the role of this approach in the ambulatory surgery unit? And in what types ...
Given that IV opioids are known to inhibit peristalsis and GI absorption and potentially affect PK/PD and C-max/T-max profiles of oral acetaminophen and other agents, what is the rationale and what is the literature support for using the ...
What are the mechanism(s) of action by which IV acetaminophen exerts its pain-relieving properties and how is this differentiated from other agents? Why is this MOA particularly valuable and complementary as part of multimodal therapy ...
What is the concept of ERAS and how does it affect your selection of pain-relieving agents and strategies, including multimodal approaches, in the perioperative setting?
What are the advantages and disadvantages of using IV opioids as monotherapy outside the context of multimodal therapy, where other agents are used in conjunction as part of ERAS? What are the downsides of this approach?
Can you summarize the foundational role of IV acetaminophen in improving functional, pain, and LOS-related outcomes across the spectrum of surgical procedures, and therefore, its use as an effective and safe pillar agent that reduces opioid ...
While improvements in LOS are well documented with IV acetaminophen, what other global functional improvements and outcomes — ambulation, in particular — have been observed in orthopedic, colorectal, and general surgery studies evaluating ...
Given that opioids are known to inhibit peristalsis and GI absorption and potentially affect PK/PD profiles of oral acetaminophen and other agents, what is the rationale for using the IV form of acetaminophen for ERAS and other dimensions ...
Given the existence of other non-opioid IV agents that have been explored as co-therapies to achieve ERAS, why do you believe IV acetaminophen may have properties — efficacy, safety profile and MOA — that are superior to other agents in ...
Given the known and problematic side effects of IV opioids — respiratory depression, nausea, vomiting, decreased oxygen saturation, and other effects on GI motility and absorption — what role does IV acetaminophen play in reducing opioid ...