FEATURED AUTHORITIES ON POST-OPERATIVE PAIN MANAGAMENT
Co-Medical Director of Bariatric Surgery
St Luke’s University Hospital
Medical Director Heart, Vascular & Critical Care Services
Baystate Medical Center
Duke University School of Medicine
Departments of Outcomes Research and General Anesthesiology
Director, Acute Pain Management Service
Thomas Jefferson University
iQ&A interactive Medical Intelligence Zone welcomes your questions and your participation in the iQ&A community.
What is the importance of opioid avoidance as a foundational strategy for multimodal pain management in the perioperative setting? And where does IV acetaminophen fit into that best pain management practice equation?
What do we know about patient satisfaction as it relates to perioperative pain management, including in patients on IV acetaminophen? And what role does opioid reduction play?
How rapid is the onset of action for IV acetaminophen and when is the C-Max achieved after a 15-minute infusion? How does the IV formulation C-Max metrics compare to the oral formulation?
What is your strategy in a patient who has become intolerant of an opioid?
What other agents or perioperative physiological factors can affect absorption of oral acetaminophen, thereby making this route potentially problematic and less reliable than IV acetaminophen?
What are the contraindications to the use of IV acetaminophen?
What makes the side effect profile of IV acetaminophen uniquely suited for perioperative pain management as compared to IV opioids?
Is there a risk of acetaminophen masking a surgical infection because of its anti-pyretic effect?
What trial-based evidence do you think is most compelling to support the use of IV acetaminophen in the setting of TKR and THR — a high pain model in orthopedic surgery context? Can you summarize the data? What did we learn about the degree ...
Is the efficacy of IV acetaminophen “universal” across many types of surgical procedures?
Can you summarize the literature- and trial-based support for the use of IV acetaminophen as part of multimodal pain management in the surgical setting?
What is the clinical importance of avoiding the hepatic first-pass effect when using the IV versus oral formulation of acetaminophen, and what PK, AUC, and C-max advantages and tissue penetration/compartment effects are observed that are responsible for improved efficacy of the IV route of administration?
What is the clinical importance of avoiding the hepatic first-pass effect when using the IV versus oral formulation of acetaminophen, and what PK, AUC, and C-max advantages and tissue penetration/compartment effects are observed that are ...