What is the clinical importance of avoiding the hepatic first-pass effect when using the IV versus oral formulation of acetaminophen, and what PK, AUC, and C-max advantages and tissue penetration/compartment effects are observed that are responsible for improved efficacy of the IV route of administration?

What is the clinical importance of avoiding the hepatic first-pass effect when using the IV versus oral formulation of acetaminophen, and what PK, AUC, and C-max advantages and tissue penetration/compartment effects are observed that are responsible for improved efficacy of the IV route of administration?

What is the clinical importance of avoiding the hepatic first-pass effect when using the IV versus oral formulation of acetaminophen, and what PK, AUC, and C-max advantages and tissue penetration/compartment effects are observed that are responsible for improved efficacy of the IV route of administration?


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Presenter

Eugene Viscusi, MD

Eugene Viscusi, MD

Associate Professor Director, Acute Pain Management Service Department of Anesthesiology Thomas Jefferson University Philadelphia, Pennsylvania