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What is the optimal time for initiating IV acetaminophen? At the beginning of surgery? Before the surgical insult? What is the rationale for pre-emptive use of this pain reliever?

What is the optimal time for initiating IV acetaminophen? At the beginning of surgery? Before the surgical insult? What is the rationale for pre-emptive use of this pain reliever?

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Length-of-stay is a critical cost- and best practice metric. What have studies shown as far as the effect of IV acetaminophen on LOS and ERAS across surgical procedures?

As you know, length-of-stay (LOS) is a critical cost- and best practice metric reflecting quality of care. In light of this, what have the studies shown as far as the effect of IV acetaminophen on LOS and ERAS benchmarks across the range ...

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What are the unique advantages -- in the immediate and extended post-operative period -- of IV acetaminophen in the bariatric surgery population? How does this agent offer particular advantages in light of the GI and respiratory disturbances encountered in this patient population?

What are the unique advantages — in the immediate and extended post-operative period — of IV acetaminophen in the bariatric surgery population? How does this agent offer particular advantages in light of the GI and respiratory disturbances ...

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Given its efficacy and safety profile, across what range of surgical procedures is IV acetaminophen ideally employed as part of an ERAS strategy in the context of multimodal pain mitigation?

Given its documented efficacy and safety profile, across what range of surgical procedures and perioperative situations is IV acetaminophen ideally employed as part of an ERAS strategy in the context of multimodal pain mitigation? What ...

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What has been the role of IV acetaminophen in establishing Enhanced Recovery After Surgery (ERAS) protocols across the spectrum of surgical procedures; and what are the objectives of ERAS?

What has been the role of IV acetaminophen in establishing Enhanced Recovery After Surgery (ERAS) protocols across the spectrum of surgical procedures; and what are the objectives of the ERAS strategy? Is it part of your multimodal approach ...

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What are the mechanisms of action by which IV acetaminophen exerts pain-relieving properties and how is this different from other agents? What is the approved dosing schedule for this agent?

What are the mechanism(s) of action by which IV acetaminophen exerts its pain-relieving properties and how is this differentiated from other agents? And what is the approved dosing schedule for this agent?

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What observations argue that IV acetaminophen should be a component of multimodal pain management, whereas IV opioids should be "rescue" or "pain breakthrough"-alleviating agents?

What clinical observations argue for the position that IV acetaminophen should be a foundation component of multimodal pain management, whereas IV opioids —which while effective, are also associated with a range of problematic side effects ...

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What have we learned about the relationship between the use of IV acetaminophen as part of multimodal pain management in various surgical settings and reduction of length-of-stay outcomes?

What have we learned about the relationship between the use of IV acetaminophen as part of multimodal pain management in various surgical settings — bariatric surgery, colorectal surgery, TKR, and THR — and reduction of length-of-stay ...

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What unique aspects of your trial design do you think are worth emphasizing? What are the take-home messages about the mechanism(s) by which IV acetaminophen reduces indirect costs?

In summary, what unique aspects of your trial design (J Gastrointest Surg. 2016 Apr;20(4):715-24) do you think are worth emphasizing? And what are the take-home messages about the mechanism(s) by which IV acetaminophen reduces indirect costs?

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Are there are surgical procedures outside the context of bariatric surgery where you think this approach to pain control may provide similar advantages?

Clearly, your clinical experience has established the efficacy, safety and cost-effectiveness associated with IV acetaminophen in the setting of bariatric surgery, but are there are surgical procedures outside this context where you think ...

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How does the side effect profile of acetaminophen compare with placebo or other non-opioid agents?

How does the side effect profile of acetaminophen compare with placebo or other non-opioid agents?

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Are there situations where you might consider IV acetaminophen as monotherapy, as opposed to its use as a non-opioid agent that is part of a multimodal approach requiring rescue with opioids?

Are there any situations where you might consider the use of IV acetaminophen as part of monotherapy for certain surgical procedures, as opposed to its use as a non-opioid foundational agent that is part of a multimodal approach requiring rescue with opioids?