Course Videos
Can you provide some discrete clinical and patient profiles where fixed ratio, combination regimens consisting of a long-acting insulin and GLP-1 RA should be strongly considered?
Which patients with T2D will be the most appropriate candidates for the fixed ratio, combination regimens, i.e., iGlarLixi or iDegLira? And just how effective, tolerable, and safe are these formulations at lowering HA1c levels?
How were the trials designed that evaluated the effectiveness and safety of the fixed ratio combination of insulin glargine and lixisenatide, and what did we learn about titration strategies and mitigating side effects of each components?
From a practical, titration perspective what important clinical guidance can you provide to optimize effectiveness of the fixed ratio insulin-GLP-1 RA combination?
What level of HA1c reduction is achieved with the fixed ratio combination and how is the side effect profile of the GLP-1 RA affected by the combination formulation and the titration strategy it utilizes?
How would you approach a 65-year old patient with T2D who has reasonable control of FBG but clear documentation of PPG?
How would approach a mildly obese patient with T2D on a maximum dose of metformin who is not yet achieving FPG or PPG target goals?
Can you identify the specific composition of fixed ratio combination long-acting insulin/GLPA-1 RA formulations, and how clinicians should titrate and deploy these agents?
What is the physiological, safety, efficacy and compliance-focused rationale for combining basal insulin plus GLP-1 RA into a fixed ratio formulation? And how does this strategy impact pan-glycemic—FPG and PPG—control?
What are the cardiovascular effects of GLP-1 RAs?
What are the cardiovascular effects of GLP-1 RAs?
Who do you believe would benefit from a fixed ratio combination of a GLP-1 RA with long-acting insulin?
From an HA1c control perspective, what is the advantage of using GLP-1 RAs in combination with long-acting insulin rather than as stand-alone therapy or as add-on to metformin?