Given that IV opioids inhibit peristalsis and GI absorption and potentially affect PK/PD and C-max/T-max profiles of oral acetaminophen, what is the rationale for using IV acetaminophen?

Given that IV opioids inhibit peristalsis and GI absorption and potentially affect PK/PD and C-max/T-max profiles of oral acetaminophen, what is the rationale for using IV acetaminophen?

Given that IV opioids are known to inhibit peristalsis and GI absorption and potentially affect PK/PD and C-max/T-max profiles of oral acetaminophen and other agents, what is the rationale and what is the literature support for using the IV form of acetaminophen as opposed to the oral formulation?


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Presenter

Jeff Gadsden, MD

Jeff Gadsden, MD

Associate Professor
Duke University School of Medicine
Chief, Division of Orthopaedic, Plastic and Regional Anesthesiology
Duke University Medical Center
Chapel Hill, North Carolina