What is the importance of avoiding the hepatic first-pass effect when using IV versus oral acetaminophen, and what PK advantages and tissue penetration effects are observed?

What is the importance of avoiding the hepatic first-pass effect when using IV versus oral acetaminophen, and what PK advantages and tissue penetration effects are observed?

What is the clinical importance of avoiding the hepatic first-pass effect when using the IV versus oral formulation of acetaminophen, and what PK advantages and tissue penetration/compartment effects are observed that are responsible for improved efficacy?


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Presenter

Eugene Viscusi, MD

Eugene Viscusi, MD

Associate Professor
Director, Acute Pain Management Service
Department of Anesthesiology
Thomas Jefferson University
Philadelphia, Pennsylvania