Case Study: A 42-year-old woman presented with a painful left thigh mass, a biopsy of which showed undifferentiated sarcoma. Lung nodule submitted for genomic profiling showed LMNA-NTRK gene fusion.

Case Study: A 42-year-old woman presented with a painful left thigh mass, a biopsy of which showed undifferentiated sarcoma. Lung nodule submitted for genomic profiling showed LMNA-NTRK gene fusion.

A 42-year-old woman presented with a painful left thigh mass, a biopsy of which showed undifferentiated sarcoma. Neoadjuvant targeted therapy, radiotherapy and chemotherapy showed no response and metastases to lung. Lung nodule submitted to FMI for genomic profiling showed LMNA-NTRK gene fusion. With no other options, how might this finding influence therapy? Enroll in NTRK1 inhibitor clinical trial?


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Presenter

Prof. Matthew Krebs, MD, PhD

Prof. Matthew Krebs, MD, PhD

Clinical Senior Lecturer
Experimental Cancer Medicine
Honorary Consultant
Medical Oncology
The University of Manchester
Greater Manchester, UK