Course Videos
What are the implications of the LEADER trial for practitioners at the front lines of diabetes care? And how will it fit into the treatment algorithm?
How do the results and study design of LEADER differ from the CV outcomes study that evaluated lixisenatide in patients with T2D? Was the CV protection seen in LEADER observed in diabetic patients on statins? How does LEADER differ from the EMPA-REG study?
What results from LEADER, showing CV risk reduction with liraglutide, do you think are most important and how are they likely to change our use of GLP-1 RAs in high risk patients with T2D?
Are there next-generation GLP-1 RAs in development? How are they similar and how might they differ from currently available agents? Dosing-wise? Efficacy? Side effects? Weight loss?
In what ways do you believe the fixed-ratio combinations of insulin plus a GLP-1 RA will help overcome the barriers we have seen with intensifying insulin or GLP-RA therapy?
What is the relationship between between GLP-1 RA and body weight? What did we learn about liraglutide, dosing regimens, and body weight — specifically weight loss — from LEADER and other trials?
Why do you believe the positive results of the LEADER trial, showing CV outcome reduction with liraglutide, are different from previous trials using other GLP-1 RAs that failed to demonstrate CV risk reduction?
How do the fixed-ratio insulin formulations mitigate the side effects associated with either insulin alone or a GLP-1 RA given alone?
What is the physiologic and mechanistic rationale for using a fixed-ratio combination insulin plus GLP-1 receptor agonist such as iDegLira and iGlarLixi that are or will be part of the treatment landscape?
Given the rather modest reductions in such CV risk factors as BP and weight, what do you believe might be the mechanistic or physiologic effects that explain the significant reduction in CV outcomes observed in LEADER?
What were the specific clinical and CV risk profiles of the patients studied in LEADER? And how will this help us identify patients who might benefit from liraglutide?
As an investigator for LEADER, what features of this study with respect to CV and mortality outcomes deserve special emphasis? How do they differ from other CV outcome trials in diabetes?