Nir Peled, MD [7505]


What is the unique status of hybrid capture NGS within the context of molecular target-driven therapy for solid tumors?

What is the unique status of hybrid capture NGS within the context of molecular target-driven therapy for solid tumors?

What advances in therapeutic targeting with NGS comprehensive genomic profiling and multiplex testing have we witnessed in patients with NSCLC?

What advances in therapeutic targeting with NGS comprehensive genomic profiling and multiplex testing have we witnessed in patients with NSCLC?

Can you bring genomic profiling down to the oncologist-patient level and explain what a FoundationOne Report is, how long it takes to generate, and what the translational value is?

Can you bring comprehensive genomic profiling down to the oncologist-cancer patient level and explain what a FoundationOne Report looks like, what information it contains, how long it takes to generate a report and what the translational ...

What is the rationale for using a validated genomic profiling platform that uses high sensitivity, hybrid capture-based NGS methodology to assess molecular drivers in solid tumors?

What is the rationale for using a validated genomic profiling platform that uses high sensitivity, hybrid capture-based NGS methodology to assess molecular drivers in solid tumors?

What is the additional clinical value of using a hybrid capture-based NGS platform? Can you discuss in terms of false-negativity and sensitivity analyses?

What is the additional clinical value of using a hybrid capture-based NGS platform? Can you discuss in terms of false-negativity and sensitivity analyses?

What is the importance of finding EGFR-sensitizing mutations such as exon 19 or exon 21 in NSCLC? What is their relationship to sensitivity to TKIs, such as erlotinib, gefitinib, and afatinib?

What is the importance of finding EGFR-sensitizing mutations such as exon 19 or exon 21 in NSCLC? What is their relationship to sensitivity to TKIs, such as erlotinib, gefitinib, and afatinib?

What other gene rearrangements (ie, gene fusions) have recently been identified (such as ROS1, BRAF, RET) that are susceptible to targeted therapies? What are the current clinical implications for testing?

What other gene rearrangements (ie, gene fusions) have recently been identified (such as ROS1, BRAF, RET) that are susceptible to targeted therapies? What are the current clinical implications for testing?

What is the role of liquid biopsies and hybrid capture NGS in the face of our understanding that there is sub-clonal evolution in many solid tumors?

What is the role of liquid biopsies and hybrid capture NGS in the face of our understanding that there is sub-clonal evolution in many solid tumors?