Jonathan Kay, MD

Jonathan Kay, MD
 

Director of Clinical Research
Rheumatology Division
Professor of Medicine
University of Massachusetts Medical School
Worcester, MA


How should one "sequence" therapy in patients who require biologic therapy? Is there a "one-sequence-fits-all" strategy? Can one start with any biologic agent in conjunction with methotrexate?

How should one optimally “sequence” therapy in patients who require biologic therapy? Is there a “one-sequence-fits-all” strategy? Or can one start with any of the biologic agents as an initial therapy in conjunction with methotrexate?

Should biologically-naive patients be approached differently from patients on previous B-DMARD therapy, but have suboptimal clinical results? What is the role of IL-6 inhibitors in this population?

Should biologically-naïve patients be approached differently from patients who have been on a previous B-DMARD therapy, but have suboptimal clinical results? What is the role of IL-6 inhibitors in this population?

Can you discuss the design and results of the TARGET trial?

Can you discuss the design and results of the TARGET trial?

How, why, and where should IL-6 cytokine inhibitors fit into evidence- and/or expert-based roadmaps for sequential approaches to RA management?

How, why, and where should IL-6 cytokine inhibitors fit into evidence- and/or expert-based roadmaps for sequential approaches to RA management?

What are predictors of risk progression and/or poor therapeutic response in RA that would make a patient appropriate for early, aggressive therapy with biologic therapy?

What are predictors of risk progression and/or poor therapeutic response in RA that would make a patient appropriate for early, aggressive therapy with biologic therapy?

Can the Simplified Disease Activity Index (SDAI) provide predictive information that guides aggressiveness of therapy for RA?

Can the Simplified Disease Activity Index (SDAI) provide predictive information that guides aggressiveness of therapy for RA?

What are the major unmet needs in patients with RA?

What are the major unmet needs in patients with RA?