Jeeyun Lee, MD
Department of Hematology and Oncology
Samsung Medical Center
SungKyunKwan University School of Medicine
Seoul, Korea
What is the evidence supporting the observation that a systematic and comprehensive NGS-generated profiling of actionable alterations in genes associated with solid tumors should or can inform therapeutic decision-making?
Since Hot Spot profiling is inadequate for detecting copy number alterations and rearrangements, which critical and actionable tumor-specific molecular targets are likely to be missed by Hot Spot profiling as opposed to CGP and why is ...
How does massively parallel (or ‘next-generation’) DNA sequencing overcome the following practical considerations regarding pathological tumor specimens? (1) Using FFPE specimens, a process that may damage DNA? (2) Accommodating limited ...
Why are current genomic testing models based on targeted sequencing (“Hot Spot”) unsustainable and more limited than comprehensive genomic profiling (CGP) developed by FoundationOne?
What are the published top-line findings of exploratory studies in which FoundationOne NGS genomic profiling targeting 145 “cancer-relevant”genes is applied to colorectal cancer and gastric cancer?
Does FoundationOne’s comprehensive genomic profiling have validation studies confirming accuracy across multiple alterations in a peer-reviewed journal? Please discuss. Do you know of any other genomic profiling services that are clinically ...