Jean-Yves Blay, MD, PhD

Prof. Jean-Yves Blay, MD, PhD
 

Professor of Medicine
Université Claude Bernard
Lyon, France
Scientific Director
Canceropole Lyon Rhône Alpes


What is your detailed analysis of the results from ProfiLER Study evaluating NGS-based, whole exome molecular profiling in patients with advanced or refractory cancer?

What is your detailed analysis of the results from ProfiLER Study evaluating NGS-based, whole exome molecular profiling in patients with advanced or refractory cancer?

What is the significance of the FDA approval of PD-1 inhibitors for tumors with MSI? What other canonical driver mutations -- BRAF, ALK, and others -- of similar significance are coming?

What do you see as the significance of the FDA approval of PD-1 inhibitors for all tumors with MSI? What other canonical driver mutations — BRAF, ALK, and others — of similar significance do you see coming down the road?

When evaluating receptivity of a patient and tumor to immune checkpoint blockade, why are total mutational burden and genomic stability as important as expression of the IC receptor?

When evaluating the receptivity of a patient and tumor to immune checkpoint blockade, why are total mutational burden and genomic stability — chromosome deletions and additions — as important as expression of the IC receptor?

Based on the evidence available, how should we be integrating and incorporating ctDNA profiling — liquid biopsies — with tissue-based whole exome NGS, including longitudinal biopsies?

Based on the evidence available, how should we be integrating and incorporating ctDNA profiling — liquid biopsies — with tissue-based whole exome NGS, including longitudinal biopsies?

Can you describe a patient example and tumor type where whole exome sequencing (WES) with NGS generated an effective treatment option that would not have emerged empirically without NGS?

Can you describe a specific patient example and tumor type where whole exome sequencing (WES) with NGS generated a safe and effective treatment option that would not have emerged empirically without NGS?