Hertzel Gerstein, MD

Hertzel Gerstein, MD
 

Professor of Medicine
McMaster University Faculty of Health Sciences
Hamilton, Ontario, Canada


What is the physiologic rationale of combining GLP-1 RAs and basal insulin into fixed ratio combination agents such as iGlarLixi and iDegLira?

What is the physiologic rationale of combining GLP-1 RAs and basal insulin into fixed ratio combination agents such as iGlarLixi and iDegLira?

What is the role of PPG in comprehensive HA1c level control? How early in T2D management do you think fixed ratio, combination basal insulin-GLP-1 RA formulations play a role?

What is the role of PPG as a determinant of achieving comprehensive HA1c level control? And how early in the course of T2D management do you think fixed ratio, combination basal insulin-GLP-1 RA formulations play a role?

What are the still unanswered questions about combination basal insulin-GLP-1 RA formulations?

What are the still unanswered questions about combination basal insulin-GLP-1 RA formulations?

What is your interpretation of the results from the studies evaluating the effectiveness and safety of fixed ratio insulin-GLP-1 RA combinations?

What is your interpretation of the results from the studies evaluating the effectiveness and safety of fixed ratio insulin-GLP-1 RA combinations?

For what reasons does insulin remain a foundational therapy for managing patients with T2D? And why does the addition of a GLP-1 RA potentially augment the utility of insulin-based management?

For what reasons does insulin remain a foundational therapy for managing patients with T2D? And why does the addition of a GLP-1 RA potentially augment the utility of insulin-based management?