Hertzel Gerstein, MD
Professor of Medicine
McMaster University Faculty of Health Sciences
Hamilton, Ontario, Canada
What is the physiologic rationale of combining GLP-1 RAs and basal insulin into fixed ratio combination agents such as iGlarLixi and iDegLira?
What is the role of PPG as a determinant of achieving comprehensive HA1c level control? And how early in the course of T2D management do you think fixed ratio, combination basal insulin-GLP-1 RA formulations play a role?
What are the still unanswered questions about combination basal insulin-GLP-1 RA formulations?
What are the still unanswered questions about combination basal insulin-GLP-1 RA formulations?
What is your interpretation of the results from the studies evaluating the effectiveness and safety of fixed ratio insulin-GLP-1 RA combinations?
For what reasons does insulin remain a foundational therapy for managing patients with T2D? And why does the addition of a GLP-1 RA potentially augment the utility of insulin-based management?