Errol R. Norwitz, MD, PhD – Applying NIPT to Clinical Practice

Errol R. Norwitz, MD, PhD, MBA
 

Louis E. Phaneuf Professor of Obstetrics & Gynecology
Tufts University School of Medicine
Chairman, Department of Obstetrics & Gynecology
Tufts Medical Center
Boston, MA

Why is SNP-based prenatal testing on women with twins clinically important and why is there an urgency to make the diagnosis and initiate evaluation to determine chorionicity and zygosity? Can you provide an overview of how NIPT and surveillance in twins can improve clinical outcomes and reduce the incidence of possible complications? Video

Why is SNP-based prenatal testing on women with twins clinically important and why is there an urgency to make the diagnosis and initiate evaluation to determine chorionicity and zygosity? Can you provide an overview of how NIPT and surveillance in twins can improve clinical outcomes and reduce the incidence of possible complications?

Why is SNP-based prenatal testing on women with twins clinically important and why is there an urgency to make the diagnosis and initiate evaluation to determine chorionicity and zygosity? Can you provide an overview of how NIPT and surveillance ...
What are the most important complexities and/or complications-i.e., cord entanglement, singleton demise, or twin-to-twin transfusion syndrome-encountered in twin pregnancies? Video

What are the most important complexities and/or complications-i.e., cord entanglement, singleton demise, or twin-to-twin transfusion syndrome-encountered in twin pregnancies?

What are the most important complexities and/or complications-i.e., cord entanglement, singleton demise, or twin-to-twin transfusion syndrome-encountered in twin pregnancies; and why do they provide a rationale for early and systematic ...
How can a SNP-based test performed as early as 9 weeks help reduce the risk of potential complications of twin-to-twin transfusion syndrome? In what way is ultrasound less accurate than NIPT in diagnosing monochorionicity in a twin pregnancy and its associated complications? Video

How can a SNP-based test performed as early as 9 weeks help reduce the risk of potential complications of twin-to-twin transfusion syndrome? In what way is ultrasound less accurate than NIPT in diagnosing monochorionicity in a twin pregnancy and its associated complications?

How can a SNP-based test performed as early as 9 weeks help reduce the risk of potential complications of twin-to-twin transfusion syndrome? In what way is ultrasound less accurate than NIPT in diagnosing monochorionicity in a twin pregnancy ...
Why is it important to recognize mono- or dichorionicity early? How accurate is ultrasound in making the distinction of monozygous, monochorionic twins based on results of recent studies? Video

Why is it important to recognize mono- or dichorionicity early? How accurate is ultrasound in making the distinction of monozygous, monochorionic twins based on results of recent studies?

Why is it important to recognize mono- or dichorionicity early in gestation? How accurate-i.e. insensitive-is ultrasound (US) in making the critical distinction of monozygous, monochorionic twins based on results of recent clinical studies?
Why is SNP-based prenatal testing supplanting US as the definitive test to distinguish chorionicity and zygosity? And how early can this test be performed? Video

Why is SNP-based prenatal testing supplanting US as the definitive test to distinguish chorionicity and zygosity? And how early can this test be performed?

Why is SNP-based prenatal testing supplanting US as the definitive test to distinguish chorionicity and zygosity? And how early can this test be performed?
What distinguishes the Natera Panorama SNP-based test in the setting of twin pregnancy from other NIPT tests used for aneuploidies? Video

What distinguishes the Natera Panorama SNP-based test in the setting of twin pregnancy from other NIPT tests used for aneuploidies?

What distinguishes the Natera Panorama SNP-based test in the setting of twin pregnancy from other NIPT tests used for aneuploidies?
How sensitive is the Panorama SNP-based NIPT test in twins? Apparently, it can report zygosity even for fetal fractions as low as 2.8%. Please explain the importance of this. Video

How sensitive is the Panorama SNP-based NIPT test in twins? Apparently, it can report zygosity even for fetal fractions as low as 2.8%. Please explain the importance of this.

How sensitive is the Panorama SNP-based NIPT test in twins? Apparently, it can report zygosity even for fetal fractions as low as 2.8%. Please explain the importance of this.
How effective is the SNP-based platform for determining gender of the fetus? Video

How effective is the SNP-based platform for determining gender of the fetus?

How effective is the SNP-based platform for determining gender of the fetus?
What are the reasons why a woman and/or family would want to know the gender of a fetus in a twin pregnancy? When during gestation can the SNP-based test be performed? Video

What are the reasons why a woman and/or family would want to know the gender of a fetus in a twin pregnancy? When during gestation can the SNP-based test be performed?

What are the medical, social, and familial reasons for why a woman and/or family of would want to know the gender of a fetus in a twin pregnancy? At what time point during gestation can the SNP-based test be performed?
What information can SNP-based NIPT in twin pregnancy provide in the setting of egg donor or surrogate pregnancies? Video

What information can SNP-based NIPT in twin pregnancy provide in the setting of egg donor or surrogate pregnancies?

What information can SNP-based NIPT in twin pregnancy provide in the setting of egg donor or surrogate pregnancies?
What are the unique advantages of SNP-based testing for twin pregnancies? What aneuploidies are detected and what other information-gender determination, zygosity, chorionicity-is available to optimize management of these pregnancies? Video

What are the unique advantages of SNP-based testing for twin pregnancies? What aneuploidies are detected and what other information-gender determination, zygosity, chorionicity-is available to optimize management of these pregnancies?

What are the unique advantages of SNP-based testing for twin pregnancies? What aneuploidies are detected and what other information-gender determination, zygosity, chorionicity-is available to optimize management of these pregnancies?
Based on currently available SNP-based testing platforms for NIPT-including the Panorama test-and results of clinical studies, can you provide a clinical practice roadmap for the foundational role and actionable information (chorionicity, zygosity, sex determination, aneuplodies) made available by SNP-based NIPT in twin pregnancies? Video

Based on currently available SNP-based testing platforms for NIPT-including the Panorama test-and results of clinical studies, can you provide a clinical practice roadmap for the foundational role and actionable information (chorionicity, zygosity, sex determination, aneuplodies) made available by SNP-based NIPT in twin pregnancies?

Based on currently available SNP-based testing platforms for NIPT-including the Panorama test-and results of clinical studies, can you provide a clinical practice roadmap for the foundational role and actionable information (chorionicity, ...