Ahmed M. Al-Malt, MD

Ahmed M. Al-Malt, MD
 

Maternal and Fetal Medicine
Obstetrics and Gynecology
Assistant Professor
University of Central Florida College of Medicine
Orlando, FL

How and when was NIPT first implemented in prenatal screening? And why is this test essential for an accurate evaluation of the pregnant patient at multiple levels of risk? Video

How and when was NIPT first implemented in prenatal screening? And why is this test essential for an accurate evaluation of the pregnant patient at multiple levels of risk?

How and when was NIPT first implemented in prenatal screening? And why is this test essential for an accurate evaluation of the pregnant patient at multiple levels of risk?
Ahmed M. Al-Malt, MD

Ahmed M. Al-Malt, MD

How has NIPT changed the landscape of prenatal testing? And what are the specific advantages that accrue to patients who undergo NIPT? Video

How has NIPT changed the landscape of prenatal testing? And what are the specific advantages that accrue to patients who undergo NIPT?

How has NIPT changed the landscape of prenatal testing? And what are the specific advantages that accrue to patients who undergo NIPT?
Ahmed M. Al-Malt, MD

Ahmed M. Al-Malt, MD

How has NIPT progressed from first to second generation testing? And what specific delineation does the evolution to SNP-based testing make possible? Video

How has NIPT progressed from first to second generation testing? And what specific delineation does the evolution to SNP-based testing make possible?

How has NIPT progressed from first to second generation testing? And what specific delineation does the evolution to SNP-based testing make possible?
Ahmed M. Al-Malt, MD

Ahmed M. Al-Malt, MD

How will the evaluation of cffDNA change the approach to prenatal screening for genetic disorders beyond the common aneuploidies in the future? Does this approach deserve widespread application across multiple risk groups, and if so, why? Video

How will the evaluation of cffDNA change the approach to prenatal screening for genetic disorders beyond the common aneuploidies in the future? Does this approach deserve widespread application across multiple risk groups, and if so, why?

How will the evaluation of cffDNA change the approach to prenatal screening for genetic disorders beyond the common aneuploidies in the future? Does this approach deserve widespread application across multiple risk groups, and if so, why?
Ahmed M. Al-Malt, MD

Ahmed M. Al-Malt, MD

How does SNP-based NIPT technology offer distinct advantages for NIPT? Video

How does SNP-based NIPT technology offer distinct advantages for NIPT?

How does SNP-based NIPT technology offer distinct advantages for NIPT?
Ahmed M. Al-Malt, MD

Ahmed M. Al-Malt, MD

How does SNP-based NIPT compare to maternal serum screening (MSS) with respect to sensitivity, specificity, false negative rates, false positive rates, and positive predictive value (PPV)? Video

How does SNP-based NIPT compare to maternal serum screening (MSS) with respect to sensitivity, specificity, false negative rates, false positive rates, and positive predictive value (PPV)?

How does SNP-based NIPT compare to maternal serum screening (MSS) with respect to sensitivity, specificity, false negative rates, false positive rates, and positive predictive value (PPV) in a real world patient population?
Ahmed M. Al-Malt, MD

Ahmed M. Al-Malt, MD

Why does utilization of NIPT in place of MSS reduce the number of women who receive a false positive screening result and the associated anxiety? Please explain why the accuracy of these tests differ. Video

Why does utilization of NIPT in place of MSS reduce the number of women who receive a false positive screening result and the associated anxiety? Please explain why the accuracy of these tests differ.

Why does utilization of NIPT in place of MSS reduce the number of women who receive a false positive screening result and the associated anxiety? Please explain why the accuracy of these tests differ.
Ahmed M. Al-Malt, MD

Ahmed M. Al-Malt, MD

Although triploidy is one of the most common chromosome abnormalities identified in human conceptions, why does the counting methodology fail to detect triploidy? Video

Although triploidy is one of the most common chromosome abnormalities identified in human conceptions, why does the counting methodology fail to detect triploidy?

Although triploidy is one of the most common chromosome abnormalities identified in human conceptions, why does the counting methodology fail to detect triploidy?
Ahmed M. Al-Malt, MD

Ahmed M. Al-Malt, MD

How should the MFM specialist or OB-GYN follow for each of the following NIPT results: (1) no result, no redraw recommended; (2) no result, redraw recommended; high risk; low risk; other? Video

How should the MFM specialist or OB-GYN follow for each of the following NIPT results: (1) no result, no redraw recommended; (2) no result, redraw recommended; high risk; low risk; other?

In your view, how should the MFM specialist or OB-GYN follow for each of the following results obtained as part of NIPT: (1) no result, no redraw recommended; (2) no result, redraw recommended; high risk; low risk; other?
Ahmed M. Al-Malt, MD

Ahmed M. Al-Malt, MD

Are patients with a low fetal fraction at increased risk for aneuploidy? If so, why? Video

Are patients with a low fetal fraction at increased risk for aneuploidy? If so, why?

Are patients with a low fetal fraction at increased risk for aneuploidy? If so, why?
Ahmed M. Al-Malt, MD

Ahmed M. Al-Malt, MD

What is the likelihood that a patient with a low fetal fraction result is able to obtain a result on repeat draw? Video

What is the likelihood that a patient with a low fetal fraction result is able to obtain a result on repeat draw?

What is the likelihood that a patient with a low fetal fraction result is able to obtain a result on repeat draw?
Ahmed M. Al-Malt, MD

Ahmed M. Al-Malt, MD

We hear a lot about depth of read from various laboratories. Is depth of read more important that fetal fraction? Please explain. Video

We hear a lot about depth of read from various laboratories. Is depth of read more important that fetal fraction? Please explain.

We hear a lot about depth of read from various laboratories. Is depth of read more important that fetal fraction? Please explain.
Ahmed M. Al-Malt, MD

Ahmed M. Al-Malt, MD

Physicians frequently encounter false positives for monosomy X with NIPT. What is the reason for this finding? Video

Physicians frequently encounter false positives for monosomy X with NIPT. What is the reason for this finding?

Physicians frequently encounter false positives for monosomy X with NIPT. What is the reason for this finding?
Ahmed M. Al-Malt, MD

Ahmed M. Al-Malt, MD

How often do you see incorrect fetal sex results with NIPT? Video

How often do you see incorrect fetal sex results with NIPT?

How often do you see incorrect fetal sex results with NIPT?
Ahmed M. Al-Malt, MD

Ahmed M. Al-Malt, MD

Is it appropriate to offer NIPT to a patient with a known vanished twin? Video

Is it appropriate to offer NIPT to a patient with a known vanished twin?

Is it appropriate to offer NIPT to a patient with a known vanished twin?
What are microdeletions and what is the rationale for offering screening for microdeletions using NIPT? Which microdeletions are of special importance? Video

What are microdeletions and what is the rationale for offering screening for microdeletions using NIPT? Which microdeletions are of special importance?

What are microdeletions and what is the rationale for offering screening for microdeletions using NIPT? Which microdeletions are of special importance?
Ahmed M. Al-Malt, MD

Ahmed M. Al-Malt, MD

How does SNP-based technology compare with the counting method when you are utilizing cffDNA to identify women at risk for carrying microdeletion syndromes? Video

How does SNP-based technology compare with the counting method when you are utilizing cffDNA to identify women at risk for carrying microdeletion syndromes?

How does SNP-based technology compare with the counting method when you are utilizing cffDNA to identify women at risk for carrying microdeletion syndromes?
Ahmed M. Al-Malt, MD

Ahmed M. Al-Malt, MD

What are some of the possible causes of false positive results, and how does the SNP method aid the physician in ruling out maternal sex chromosome mosaicism abnormalities? Video

What are some of the possible causes of false positive results, and how does the SNP method aid the physician in ruling out maternal sex chromosome mosaicism abnormalities?

What are some of the possible causes of false positive results, and how does the SNP method aid the physician in ruling out maternal sex chromosome mosaicism abnormalities?
Ahmed M. Al-Malt, MD

Ahmed M. Al-Malt, MD

Is NIPT appropriate for pregnant women who are at average risk for chromosomal abnormalities? Please explain the pros and cons. Video

Is NIPT appropriate for pregnant women who are at average risk for chromosomal abnormalities? Please explain the pros and cons.

Is NIPT appropriate for pregnant women who are at average risk for chromosomal abnormalities? Please explain the pros and cons.
Ahmed M. Al-Malt, MD

Ahmed M. Al-Malt, MD

Can you summarize how, when, and whom you utilize NIPT in your own practice? Video

Can you summarize how, when, and whom you utilize NIPT in your own practice?

Can you summarize how, when, and whom you utilize NIPT in your own practice?
Ahmed M. Al-Malt, MD

Ahmed M. Al-Malt, MD