Focus on IL-6 Inhibitors for Optimizing Multimodal Management of RA
A Real World Approach to Unmet Needs, Patient-Centric Care, Special Populations, and Sequencing Biologic Therapies for Rheumatoid Arthritis (RA)
A Real World Approach to Unmet Needs, Patient-Centric Care, Special Populations, and Sequencing Biologic Therapies for Rheumatoid Arthritis (RA)
Course Videos
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What are the potential inflammatory interfaces that are affected by inhibition of the IL-6 cytokine pathway? How does each pathway potentially affect clinical manifestations of RA?
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Are IL-6 inhibitors synergistic with methotrexate and how do they compare to TNFIs as far as their efficacy as monotherapy in patients with RA?
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What is the precise immunopathobiologic mechanism of action (MoA) for agents targeting IL-6 in the setting of RA? How does IL-6 affect bone loss in RA?
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What adverse effects should clinicians be aware of when treating RA patients with IL-6 inhibitors?
What adverse effects should clinicians be aware of when treating RA patients with IL-6 inhibitors?
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What are the risks for infection when treating RA patients with biologics?
What are the risks for infection when treating RA patients with biologics?
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What metabolic or hematologic markers should we monitor in patients on IL-6 therapy?
What metabolic or hematologic markers should we monitor in patients on IL-6 therapy?
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What is your assessment of the cardiovascular risk profile associated with IL-6 therapy? And the possible role of IL-6 inhibition as a mitigator of any effects related to LDL elevation?
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When a suboptimal clinical response has been encountered with a traditional DMARD, what therapeutic approaches for escalating therapy are appropriate?
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When a suboptimal clinical response has been encountered with TNF, do you recommend switching to a biologic with a different MoA, such as an IL-6 inhibitor or co-modulating agent?
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Among the biologic agents, are there any significant efficacy or safety differentiators that prompt you to deploy one agent in preference to another, in any particular sequence?
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How long of a trial using traditional DMARD therapy with methotrexate do you recommend prior to intensifying treatment with a biologic agent?
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What are the strategies for individualizing treatment in patients with RA?
What are the strategies for individualizing treatment in patients with RA?