Intended Audience

This complimentary CME educational activity is designed for all cardiology-focused physicians, nurses, NPs, academicians, pharmacists, researchers, investigators, and program directors managing, referring, and/or consulting on patients with atrial fibrillation, with a focus on stroke prevention. We welcome neurology-focused clinicians with a medical and educational needs in the fields of general cardiology, and other providers that are part of the multidisciplinary team caring for patients with these and related conditions, including:

Program Medium

Internet-based program

Method of Physician Participation Utilized in Learning Process

There are no fees for participating and receiving CME credit for this activity. During the period October 5, 2012 through October 5, 2014 participants must 1) read the learning objectives and faculty disclosures; 2) study the educational activity, and are expected to view all 174 segments totaling 7 hours to successfully complete the activity and earn CME credit; 3) register and complete the evaluation form and post-test; 4) score 100% on the post-test; and 5) print out CME certificate

Estimated Time to Complete Educational Activity

7.0 hours

Course Overview

In this web-based program, physicians will learn how recent advances in basic and clinical research have helped to advance the understanding of treatment advances in stroke prevention in the setting of atrial fibrillation.

Release Date

October 5, 2012

Expiration Date

October 5, 2014


Participation in this iQ&A interactive Medical Intelligence Zone for Stroke Prevention in Atrial Fibrillation is complimentary, and clinicians are invited to view this CME-certified program and/or share this invitation with other colleagues, departmental staff members, and healthcare professionals.

Grantor Support

Supported by an educational grant from the Bristol-Myers Squibb/Pfizer Partnership

Accreditation Statement

This activity has been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of the University of Massachusetts Medical School Office of Continuing Medical Education (UMMS-OCME) and CMEducation Resources, LLC. The UMMS-OCME is accredited by the ACCME to provide continuing medical education for physicians.

Credit Designation Statement

The University of Massachusetts Medical School designates this enduring material for a maximum of 7.0 AMA PRA Category 1 Credits(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Policy on Faculty & Provider Disclosure

It is the policy of the University of Massachusetts Medical School to ensure fair balance, independence, objectivity and scientific rigor in all activities. All faculty participating in CME activities sponsored by the University of Massachusetts Medical School are required to present evidence-based data, identify and reference off-label product use and disclose all relevant financial relationships with those supporting the activity or others whose products or services are discussed. Faculty disclosure will be provided in the activity materials.

Program Faculty and Disclosure

Samuel Z. Goldhaber, MD
Program Chairman and Moderator
Professor of Medicine
Harvard Medical School
Director, VTE Research Group
Cardiovascular Division
Brigham and Women's Hospital
President, North American Thrombosis Forum (NATF)
Boston, Massachusetts

Advisor or consultant: Boehringer Ingelheim Pharmaceuticals, Inc., Bristol-Myers Squibb, Eisai, and sanofi-aventis.
Research support: Boehringer Ingelheim Pharmaceuticals, Bristol-Myers Squibb, Eisai, Johnson & Johnson Pharmaceutical Research & Development and sanofi-aventis

John Amerena, MD
Geelong Cardiology Research Centre
Deakin University
Victoria, Australia

Nothing to disclose

Dan Atar, MD, PhD
Department of Cardiology
Oslo University Hospital Ullevaal
Oslo, Norway

Speaker and Consultant: BMS/Pfizer, Bayer, Boehringer-Ingelheim, Merck, sanofi-aventis

Jean-Pierre Bassand, MD
Professor of Cardiology
University of Besançon
Chief, Department of Cardiology
University Hospital Jean-Minjoz
Besançon, France

Consultant: AstraZeneca Pharmaceuticals LP; Bayer HealthCare Pharmaceuticals; Iroko Pharmaceuticals, LLC; sanofi-aventis
Speaker’s Bueaaru: AstraZeneca Pharmaceuticals LP; Bayer HealthCare Pharmaceuticals; Eli Lilly and Company; GlaxoSmithKline; Iroko Pharmaceuticals, LLC Stock: Eli Lilly and Company; GlaxoSmithKline; sanofi-aventis

Deepak L. Bhatt, MD, MPH, FACC, FAHA, FSCAI
Chief of Cardiology, VA Boston Healthcare System
Director, Integrated Interventional Cardiovascular
Program, Brigham and Women’s Hospital and the
VA Boston Healthcare System
Senior Investigator, TIMI Group
Harvard Medical School
Boston, Massachusetts

Consultant: Arena, Astra Zeneca, Bristol-Myers Squibb, Cardax, Cogentus, Daiichi Sankyo, Eli Lilly, Eisai, Glaxo Smith Kline, Johnson & Johnson, Medtronic, Millennium, Otsuka, Paringenix, PDL, Philips, Portola, sanofi-aventis, Schering Plough, Takeda, The Medicines Company, Vertex.
Principal Investigator for several potentially related studies. His institution has received funding from Bristol Myers Squibb, Eisai, Ethicon, Heartscape, sanofi-aventis, The Medicines Company

Robert Califf, MD
DTMI Director
Donald F. Fortin, M.D. Professor of Cardiology, School of Medicine
Vice Chancellor for Clinical and Translational Research
Principal Investigator, The MURDOCK Study
Durham, North Carolina (USA)

Advisor/consultant: Johnson & Johnson Pharmaceutical Research & Development, L.L.C.; Kowa Company Ltd.; Nile Therapeutics, Inc.; Orexigen Therapeutics, Inc.; Parkview; POZEN Inc.; SERVIER
Owns stock, stock options, or bonds from: Nitrox, LLC

John W. Eikelboom, MD
Associate Professor of Medicine
McMaster University
Canada Research Chair in Cardiovascular Medicine

Advisory Board/Consultant: AstraZeneca, Boehringer Ingelheim, Bristol-Myers Squibb, Daiichi Sankyo, Eisai, Eli Lilly and Company, GlaxoSmithKline, Haemoscope, McNeil Consumer Healthcare, Sanofi US
Grant/Research Support: Accumetrics, AspirinWorks, Bayer, Boehringer Ingelheim, Bristol-Myers Squibb, Corgenix, Dade Behring, GlaxoSmithKline, Sanofi US.

Greg Flaker MD
Professor of Medicine
Wes and Simon Chair of Cardiovascular Research
University of Missouri School of Medicine
Columbia, MO

Consultant: Boehringer-Ingelheim
Grant/Research Support: Boehringer-Ingelheim

S. Ben Freedman, MB, PhD, FACC
ANZAC Research Institute
Concord Hospital
Faculty of Medicine
University of Sydney
Sydney, Australia

Grant/Research Support: Boehringer-Ingelheim, Bristol-Myers Squibb, Pfizer
Advisory Board: Bayer

Christopher B. Granger, MD
Professor of Medicine
Cardiac Care Unit; Co-Director
Cardiovascular Clinical Trials
Duke University Medical Center
Durham, North Carolina

Advisor or Consultant: AstraZeneca Pharmaceuticals LP; Boehringer Ingelheim Pharmaceuticals, Inc.; Bristol-Myers Squibb Company; GlaxoSmithKline; F. Hoffmann-La Roche Ltd; Novartis Pharmaceuticals Corporation; Otsuka Pharmaceutical Co., Ltd.; sanofi-aventis; The Medicines Company
Grants/Research Support: Astellas Pharma, Inc.; AstraZeneca Pharmaceuticals LP; Boehringer Ingelheim Pharmaceuticals, Inc.; Bristol-Myers Squibb Company; GlaxoSmithKline; Eli Lilly and Company; Medtronic, Inc.; Merck & Co., Inc.; sanofi-aventis; The Medicines Company

Werner Hacke, MD
Professor of Neurology
Department of Neurology
University of Heidelberg Medical School
Heidelberg, Germany

Nothing to disclose

Jonathan L. Halperin, MD
Mount Sinai School of Medicine
Director, Clinical Cardiology Services
The Zena and Michael A. Wiener Cardiovascular Institute
The Marie-Josée and Henry R. Kravis Center for Cardiovascular Health
Mount Sinai Medical Center
New York, New York

Consultant: Astellas Pharma, U.S., Bayer HealthCare, Biotronik, Inc, Boehringer-Ingelheim, Daiichi-Sankyo Pharma, Johnson & Johnson, Portola Pharmaceuticals, Sanofi-Aventis

Stefan H. Hohnloser, MD
Director, Department of Clinical Electrophysiology
J. W. Goethe University
Frankfurt, Germany

Consultant: sanofi-aventis, Boehringer Ingelheim, St. Jude Medical, Cardiome Pharma Corp., ARYx Therapeutics, Bristol-Myers Squibb
Speaker/Speaker’s Bureau: sanofi-aventis, Boehringer Ingelheim, St. Jude Medical, Cardiome Pharma Corp., ARYx Therapeutics, Bristol-Myers Squibb
Grant/Research Support: sanofi-aventis, St. Jude Medical

Elaine M. Hylek, MD, MPH
Associate Professor of Medicine
Department of Medicine
Boston University Medical Center
Boston, Massachusetts

Advisory Boards: Bristol-Myers Squibb, sanofi-aventis, Boehringer-Ingelheim

Peter R. Kowey, MD
W.W. Smith Chair and Chief of Cardiology
Main Line Health Professor of Medicine and Clinical Pharmacology
Jefferson Medical College
Philadelphia, PA

Consultant: Daiichi-Sankyo, Boehringer-Ingelheim, Johnson & Johnson, Bristol-Myers Squibb, Merck, Portola

Jean-Yves F. Le Heuzey, MD
Professor of Cardiology
Head, Arrhythmia Department
Hôpital Européen Georges Pompidou
Paris, France

Research support/advisory boards: sanofi-aventis, Bayer, Boehringer-Ingelheim, Bristol-Myers Squibb, Pfizer, Daiichi Sankyo

Gregory Y.H. Lip, MD, FRCP, FACC, FESC
Consultant Cardiologist and Professor of Cardiovascular Medicine
Director, Haemostasis Thrombosis & Vascular Biology Unit
University of Birmingham Centre for Cardiovascular Sciences
City Hospital
Birmingham, England

Advisor or consultant: Boehringer Ingelheim Pharmaceuticals, Inc.; sanofi-aventis; Bayer HealthCare Pharmaceuticals; Merck & Co., Inc.; Astellas Pharma, Inc.; Portola Pharmaceuticals, Inc.; BIOTRONIK, Inc.; AstraZeneca Pharmaceuticals LP; Bristol-Myers Squibb Company; Pfizer Inc
Speaker or a member of a speakers bureau: Boehringer Ingelheim Pharmaceuticals, Inc.; sanofi-aventis; Bayer HealthCare Pharmaceuticals; Bristol-Myers Squibb Company; Pfizer Inc.

Renato D. Lopes, MD, PhD
Adjunct Professor of Medicine
Duke University Medical Center
Durham, NC
Federal University of São Paulo
Executive Director
Brazilian Clinical Research Institute
São Paulo, Brazil

Advisor or consultant: Boehringer Ingelheim Pharmaceuticals, Inc. Received grants for clinical research from: Bristol-Myers Squibb Company

Kenneth W. Mahaffey, MD
Associate Professor of Medicine
Duke University Health System
Faculty, Director, Clinical Events Classification (CEC) Group
Duke Clinical Research Institute
Durham, NC

Grant/Research Support: Abbott Laboratories; Amgen Inc.; Amylin Pharmaceuticals, Inc.; AstraZeneca Pharmaceuticals LP; Bayer HealthCare Pharmaceuticals; Boehringer Ingelheim; Bristol-Myers Squibb; CardioKinetix Inc.; Cierra, Inc.; Cordis Corporation; Edwards Lifesciences; Eli Lilly and Company; Genentech, Inc.; GlaxoSmithKline; Guidant Corporation; Innocoll, Inc.; Johnson & Johnson Pharmaceutical Research & Development, L.L.C.; KCI; Luitpold Pharmaceuticals; Medtronic, Inc.; Merck & Co., Inc.; Momenta Pharmaceuticals, Inc.; Novartis Pharmaceuticals; Portola Pharmaceuticals, Inc.; POZEN Inc.; Regado Biosciences; sanofi-aventis; Schering-Plough; The Medicines Company
Consultant: Adolor Corporation; Alexion Pharmaceuticals, Inc.; Amgen Inc.; Argolyn Bioscience, Inc.; AstraZeneca Pharmaceuticals LP; Bayer HealthCare Pharmaceuticals; Boehringer Ingelheim; Bristol-Myers Squibb; Daiichi Sankyo, Inc.; Duke University School of Medicine; Eli Lilly and Company; Elsevier B.V.; Forest Laboratories, Inc.; Genentech, Inc.; GlaxoSmithKline; Guidant Corporation; Johnson & Johnson Pharmaceutical Research & Development, L.L.C.; Merck & Co., Inc.; Novartis; Pfizer Inc.; Procter & Gamble; sanofi-aventis; Schering-Plough; Scios Inc

Gerald V. Naccarelli, MD
Bernard Trabin Chair in Cardiology
Professor of Medicine
Chief, Division of Cardiology
Penn State Heart and Vascular Institute
Hershey, PA

Advisor or consultant: Otsuka Pharmaceutical Co. Ltd.; Boehringer Ingelheim Pharmaceuticals, Inc.; Pfizer Inc.; AstraZeneca Pharmaceuticals LP; Paracor; Transoma; Medtronic, Inc.; sanofi-aventis; CV Therapeutics; Cardiome Pharma Corp.; Novartis Pharmaceuticals Corporation; Wyeth Pharmaceuticals Inc.; Xention; Astellas Pharma, Inc.; GlaxoSmithKline; Biocritique.
Research Support: GlaxoSmithKline; Boehringer Ingelheim Pharmaceuticals, Inc.; Boston Scientific; Medtronic, Inc.; sanofi-aventis.

Manesh R. Patel, MD
Assistant Professor of Medicine
Division of Cardiology
Duke Clinical Research Institute
Durham, North Carolina (USA)

Advisor or consultant: Bayer HealthCare Pharmaceuticals; Genzyme Corporation; Ortho-McNeil-Janssen Pharmaceuticals, Inc.
Grant/Research Support: Johnson & Johnson Pharmaceutical Research & Development, L.L.C.; MAQUET, Inc.

Leopoldo Piegas, MD, PhD, FACC
Clinical Division Director
Instituto Dante Pazzanese de Cardiologia
São Paulo, Brazil

Nothing to disclose

Tatjana Potpara, MD
Department of Cardiology
Institute for Cardiovascular Diseases
Clinical Center of Serbia
Medical Faculty, Belgrade University
Belgrade, Serbia

Advisory Board: Boehringer-Ingelheim

Alexander G. G. Turpie, MD, FRCP, FACP, FACC, FRCPC
Professor of Medicine, Emeritus
Department of Medicine
Hamilton Health Sciences-General Hospital
Hamilton, Ontario

Consultant: Bayer, Johnson & Johnson, Pfizer, Astellas
Speaker’s Bureau: GlaxoSmithKline, Bayer Canada

Lars Wallentin, MD, PhD
Professor of Cardiology
Director, Uppsala Clinical Research Center
University Hospital
Uppsala, Sweden

Grant/Research Support: AstraZeneca Pharmaceuticals LP, Boehringer Ingelheim Pharmaceuticals Inc., Bristol-Myers Squibb Company, GlaxoSmithKline, Schering-Plough Corporation

Jeffrey I. Weitz, MD FRCP, FACP
Professor of Medicine and Biochemistry
McMaster University
Canada Research Chair in Thrombosis
Heart and Stroke Foundation
J.F. Mustard Chair in Cardiovascular Research

Honoraria: Bristol-Myers Squibb, Daiichi-Sankyo, Takeda
Consultant: Boehringer-Ingelheim, sanofi-aventis, The Medicines Company, Bayer, Bristol-Myers Squibb, Eisai, Daiichi-Sankyo, Takeda

Program Managers and Web Editor Disclosure

Program Manager Gideon Bosker, MD has nothing to disclose.
Program Reviewer Denise Leary has nothing to disclose

Educational Objectives

Upon completion of this activity, participants will:


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iQ&A Interactive Medical Intelligence Zone for Advances in SPAF